CaMK regulation of CP-AMPARs was also confirmed in hippocampal slices. The ability of CaMKI, which regulates the actin cytoskeleton, to recruit synaptic CP-AMPARs was blocked by inhibiting actin polymerization with latrunculin A. Here, we report that intracellular infusion of active CaM-kinase I (CaMKI) into cultured hippocampal neurons enhances miniature EPSC amplitude because of recruitment of CP-AMPARs, likely from an extrasynaptic pool. However, intracellular signaling pathways that recruit synaptic CP-AMPARs are unknown, and involvement of CP-AMPARs in hippocampal region CA1 synaptic plasticity is controversial. Ca 2+-permeable AMPA receptors (CP-AMPARs) at central glutamatergic synapses are of special interest because of their unique biophysical and signaling properties that contribute to synaptic plasticity and their roles in multiple neuropathologies.
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The ECNs are considered part of the set of specifications-the ECNs and the issued specifications must be examined in order to fully understand specific requirements. If you have a CableLabs account, click here. Once ECNs are incorporated into the specification and the next version of the specification has been published, those incorporated ECNs will remain on the specification public webpage and also archived in InfoZone. When an Engineering Change has been approved as an Engineering Change Notice ECNit is publicly posted on the webpage of the specific specification version against which it was written. Issued specifications undergo changes through an open Engineering Change Process. Technical specifications publicly available for vendors to reference are provided in PDF format only. Interoperable devices based on common specifications facilitate consumer choice, widespread deployment of new technologies, and lower costs to both cable operators and consumers. Working in cooperation with cable companies and cable equipment manufacturers, CableLabs has developed sets of publicly available interface specifications to facilitate interoperability of cable devices, including cable modems, set-top boxes, digital televisions, and various telephony devices. |
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